Table 4. Meta-analysis of the association between Thr325Ile variant and risk of venous thrombosis in European study populations.
| Genotype Contrasts | Number of Studies | OR | 95% CI | p-value | I2 (%) | P-value for Cochran’s Q |
|---|---|---|---|---|---|---|
| Venous Thrombosis (Number of cases = 3235 and number of non-cases = 3486) | ||||||
| Allelic model | 10 | 0.94 | (0.87, 1.02) | 0.139 | 11.5% | 0.337 |
| CT vs. CC | 10 | 1.00 | (0.88, 1.14) | 0.994 | 22.6% | 0.235 |
| TT vs. CC | 10 | 0.82 | (0.70, 0.97) | 0.021 | 0.0% | 0.736 |
| TT + CT vs. CC | 10 | 0.97 | (0.85, 1.10) | 0.593 | 28.2% | 0.185 |
| TT vs. CT + CC | 10 | 0.83 | (0.71, 0.97) | 0.021 | 0.0% | 0.923 |
The primary genetic model is bolded and there was no interaction effect by sex.