TABLE II. : Correlation among live cells, dengue virus (DENV)/NS1 antigen detection and cytokine/chemokine productiona .
| Live cellsb | NS1c | DENVd | IL-6e | IL-8 | MIF | ||
|---|---|---|---|---|---|---|---|
| Live | r | t | -0.8091 | 0.7844 | -0.4767 | -0.5481 | -0.7597 |
| cells | p | < 0.0001 | < 0.0001 | 0.0336 | 0.0101 | < 0.0001 | |
| NS1 | r | -0.9156 | 0.4361 | 0.5584 | 0.8403 | ||
| p | < 0.0001 | 0.0546 | 0.0085 | < 0.0001 | |||
| DENV | r | -0,4 | -0,4909 | -0.7792 | |||
| p | 0.0806 | 0.0238 | < 0.0001 |
a: average of values from the same treatment in each point were submitted to the Spearman’s correlation test. We included samples from DENV infected Huh-7 treated with Uncaria guianensis bark extract (UGB) at concentrations 25, 10 or 5 µg/mL or U. guianensis leaf extract (UGL) treated with 5, 1 or 0.5 µg/mL at time-points of 24, 48 or 72 h; b: live cell counts per 100 µL; c: NS1 ratio; d: percent of DENV +positive cells; e: IL-6, IL-8 and macrophage migration inhibitory factor (MIF) pg/mL.