Table 1.
An association between rs17845226 and rs17191144 genotype and lipid risk factors and CHD risk in the NPHSII cohort.
| Genotype | rs17845226 (Val98Leu) |
rs17191344 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CC (n = 1868) | CA (n = 561) | AA (n = 34) | p-valuea | p-valueb | AA (n = 1956) | AG (n = 659) | GG (n = 57) | p-valuea | p-valueb | |
| TC (mmol/L) | 5.73 (1.00) | 5.80 (1.04) | 6.21 (1.05) | 0.014 | 0.007 | 5.72 (1.01) | 5.74 (1.03) | 5.96 (1.04) | 0.205 | 0.085 |
| LDL-C (mmol/L) | 3.08 (0.99) | 3.16 (1.04) | 3.66 (0.94) | 0.006d | 0.003 | 3.09 (1.00) | 3.09 (1.03) | 3.38 (1.03) | 0.302 | 0.051 |
| HDL-C (mmol/L) | 0.81 (0.24) | 0.80 (0.26) | 0.74 (0.23) | 0.456 | 0.201 | 0.81 (0.24) | 0.79 (0.25) | 0.81 (0.26) | 0.494 | 0.786 |
| TG (mmol/L)c | 1.74 (1.25–2.54) | 1.7 (1.22–2.65) | 1.74 (1.22–2.91) | 0.970 | 0.648 | 1.73 (1.24–2.53) | 1.76 (1.25–2.74) | 1.62 (1.12–2.56) | 0.465 | 0.604 |
| CHD risk by genotype | ||||||||||
| No. without CHD (%) | 1672 (75.8) | 507 (23.0) | 26 (1.2) | – | – | 1749 (73.5) | 585 (24.6) | 45 (1.9) | – | – |
| No. with CHD (%) | 196 (76.0) | 54 (20.9) | 8 (3.1) | – | – | 207 (70.7) | 74 (25.3) | 12 (4.1) | – | – |
| HR (95% CI) Model 1 | 1.00 | 0.93 (0.68–1.26) | 2.17 (1.03–4.60) | 0.578e | 0.043 | 1.00 | 1.10 (0.83–1.44) | 1.86 (1.02–3.41) | 0.113 | 0.052 |
| HR (95% CI) Model 2 | 1.00 | 0.84 (0.59–1.20) | 1.25 (0.49–3.20) | 0.573 | 0.60 | 1.00 | 0.98 (0.72–1.34) | 1.29 (0.60–2.79) | 0.787 | 0.504 |
d and e Deviation from a dominant model p = 0.051.
d and e Deviation from a dominant model p = 0.021.
Model 1: age and practice adjusted; Model 2: adjusted for age, practice and LDL-C.
a
p-value according to additive model.
b
p-value according to recessive model.
c
Median [IQR].