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Assessment of vascular contraction to phenylephrine (PE) (a) and endothelial-dependent relaxation to acetylcholine (Ach) assessed by wire myography (b). Vascular stress-strain curve (c) and wall to lumen ratio (d) assessed by pressure myography in WKY and SHRSP rats. Curves represent the mean ± SEM (n = 8–15 per group). *P < 0.05 vs WKY.
