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Blockade of mineralocorticoid receptor (MR) reduces pro-fibrotic signaling in aortas of SHRSP rats. Effects of canrenoic acid (CA) (10 mg/kg/day) treatment on vascular activation (phosphorylation) of p66Shc (a) and p38MAPK (b), and Nox1 (c) and fibronectin protein expression (d). Bars represent the mean ± SEM (n = 3–4 per group). *P < 0.05 vs WKY vehicle, †p < 0.05, ††P < 0.01 vs SHRSP vehicle. CA = canrenoic acid.
