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. 2016 Jun 27;34(31):3766–3772. doi: 10.1200/JCO.2016.66.9622

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© 2016 by American Society of Clinical Oncology

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Fig 3. — Patients in telomere content (TC) quartile one (Q1) demonstrated a longer time to absolute neutrophil count (ANC) recovery after intensification (A) two and (B) three. First-remission TC was examined for all five chemotherapy courses, relative to time to ANC recovery. TC Q1 was compared with Q2 to Q4 relative to the number of days to ANC recovery (500 cells/μL). No difference in TC was noted for the first three courses. In the fourth and fifth courses, patients in Q1 demonstrated a longer mean ANC recovery time, which was significant for both intensifications (A) two (P < .001) and (B) three (P = .002). Analysis of individual quartiles confirmed the association between less TC in Q1 and delays in ANC recovery.