Fig A1.

Both telomere content (TC) comparison groups (quartile one [Q1] and Q2 to Q4) show some degree of patient attrition over the five chemotherapy courses. Shown is a comparison of patient attrition in each TC quartile group over five chemotherapy courses. After induction two, two patients were excluded for not achieving remission. After intensification one, four patients were excluded for proceeding to hematopoietic stem-cell transplantation. After intensification two, one patient experienced relapse and was removed from the study, three withdrew because of unacceptable toxicities, and one withdrew by physician decision. Not all patients were permitted complete recovery before chemotherapy was initiated. For Q1, recovery rates to absolute neutrophil count of 500 cells/μL before receiving subsequent chemotherapy were 24 of 24 for induction one, 23 of 24 for induction two, 21 of 23 for intensification one, 20 of 22 for intensification two, and 17 of 20 for intensification three. For Q2 to Q4, recovery rates before receiving subsequent chemotherapy were 70 of 73 for induction one, 73 of 73 for induction two, 70 of 72 for intensification one, 69 of 69 for intensification two, and 64 of 66 for intensification three.