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. Author manuscript; available in PMC: 2018 Jun 30.
Published in final edited form as: J Mol Biol. 2016 Nov 26;429(13):1934–1945. doi: 10.1016/j.jmb.2016.11.019

Figure 1. Protein sequence, genomic distributions, and cancer mutations of H3.3.

Figure 1

Amino acids in H3.3 that are distinct from canonical H3 are shown in blue squares and highlighted with residue numbers. G90 is an essential amino acid recognized by UBN1 in the HIRA complex or DAXX in the DAXX/ATRX, the two known variant-specific chaperones that deposit H3.3 into distinct chromosomal regions that is highlighted in different colors in the schematic representation of chromosome. Amino acids that are mutated in human cancers are shown in red squares and highlighted with residue numbers. Mutation of K27M or K36M inhibits the enzymatic activity of EZH2 or SETD2, respectively, leading to global loss of H3K27 methylation in DIPG or H3K36 methylation in chondroblastoma. The mechanism of G34 mutations to various amino acids is current not clear. Abbreviations: A: alanine; G: glycine; I: isoleucine; K: lysine; L: leucine; M: methionine; R: arginine; S: serine; DIPG: diffuse intrinsic pontine glioma; GCTB: giant cell tumors of the bone; GBM: glioblastoma.