Schematic comparison of p518, a florfenicol resistance plasmid from A. pleuropneumoniae strain MV518, with other Pasteurellaceae plasmids. Open reading frames are indicated by arrows, with arrowheads showing direction of transcription (floR: florfenicol resistance; lysR*: partial lysR transcriptional regulator; tnp*: truncated transposase gene; mob, mobA, mobB, mobC, mobA/L: plasmid mobilisation; mobC*: partial mobC gene; repA, repB, repC: plasmid replication; sul2: sulphonamide resistance; strA: streptomycin resistance; strB*: partial strB streptomycin resistance; hyp: hypothetical gene). The predicted origins of replication (oriV; ) and transfer (oriT; ) are shown. Grey blocks between sequences indicate ≥ 98% nucleotide sequence identity. A distance scale in kb is shown.