Table 4.

Parameter estimates, CIs and goodness-of-fit from the genetic modeling for the cluster that included the orbitofrontal cortex.

Variance components			Covariance components			Geneticandenvironmental correlations		Goodness-of-fit indexa
h2	c2	e2	rph	rph-a	rph-e	rg	re	∆χ2 (P)
0.40	0.00	0.60	0.29	0.40	−0.11	0.69	−0.37	16.9 (<0.001)
(0.09–0.65)	(0.00–0.30)	(0.35–0.89)	(0.13–0.44)			(0.35–1.00)	(−0.68 to 0.02)

Parameters for bipolar disorder are fixed based on a prevalence of 1% and the following genetic model: h²=0.85, c²=0, e²=0.15. Abbreviations: CI, confidence interval; h², additive genetic effects; c², shared environment effects; e², unique environment effects; r_ph, total phenotypic correlation; r_ph-a, breakdown of the phenotypic correlation into genetic components; r_ph-e, breakdown of the phenotypic correlation into environmental components; r_g, genetic correlation; r_e, unique environmental correlation. CIs including zero indicate non-significance.

^aA ∆χ² with a significant p value indicates a good fit.