Table I.

A summary table of some therapeutics tested in the STR/ort mouse model and their outcomes

Agent	Action	Outcome	Ref.
Naloxone	Opiod antagonist	No signs of pain-associated behaviours	20
Ro 32-3555	Collagenase inhibitor	Reduction in joint space narrowing, osteophyte formation and protection against AC degradation and subchondral bone sclerosis	41
CRB0017	Anti-ADAMTS5 antibody	Dose-dependently slowed OA progression in STR/ort mice ageing from 5 to 8 months	42
Vitamins E, C, A, B6, B2, and selenium	Dietary supplementation	Lower OA incidence	65