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. 2017 May 26;7:2441. doi: 10.1038/s41598-017-02721-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of MVPs in canonical pathways related to craniofacial development. Top five canonical pathways on Ingenuity Pathway Analysis (IPA) using the 578 MVPs shows “Regulation of the Epithelial-Mesenchymal Transition Pathway”, “Wnt/B-catenin Signaling” and “PCP pathway” as significantly enriched in those MVPs. Those pathways are extensively related to craniofacial development, including lip and palate morphogenesis.