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. 2017 May 26;7:2433. doi: 10.1038/s41598-017-01150-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two-Stage Cluster Capture Operating Principles: (a) Stage 1 and Stage 2 device inlet, outlets and fluidic paths. (b) Array of cylindrical micropillars in Stage 1 deflects large clusters from other blood cells using deterministic lateral displacement. (c) A 90 µm Stage 1 ceiling allows clusters to align along the Z-axis. (d) Array of asymmetric pillars in Stage 2 deflects small clusters. (e) A 30 µm Stage 2 ceiling forces clusters to align in the X-Y plane. (f) Photograph of device running whole blood (red) with colored PBS buffer (blue) next to U.S. quarter dollar coin. (g) Diagram showing asymmetric pillars inducing cluster rotation. (h) Symmetric single cells do not deflect while asymmetric small clusters sort by their longitudinal axes in Stage 2 and large clusters sort by size in Stage 1. Schematics not to scale.