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. 2017 Jun;17(6):636–644. doi: 10.1016/S1473-3099(17)30139-1

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© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Concentration of DSM265 and DSM450 over time

Individual (spaghetti) concentration–time profiles in plasma of DSM265 (A and C) and DSM450 (B and D) following administration of a single dose of 400 mg DSM265 in cohort 1 (A and B) and cohort 2 (C and D). Participants in cohort 2 (C) who developed malaria on days 11 and 13 are shown in red, the participant with malaria on day 24 is shown in blue, and participants with submicroscopic parasitaemia without malaria are shown in purple. The green shading shows the approximate time of the first cycle of asexual parasitaemia.