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. 2017 May 26;7:2459. doi: 10.1038/s41598-017-02562-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of P2Y6 receptors in human gastric cancer cells and its association with cancer progression. (a) Immunohistochemical staining of P2Y6 receptor expression in human GC tissues and adjacent normal tissues. (b) Summary data showing the reduced expression of P2Y6 receptors in GC tissues compared to adjacent normal tissues. (c–e) The expression levels of P2Y6 receptors in GC samples from the patients with different tumor sizes, differentiation and metastasis to lymph nodes. (f) Kaplan-Meier analysis of different expression levels of P2Y6 receptors with the survival of GC patients. *p < 0.05, ***p < 0.001, n = 50. Image-Pro Plus 6.0 was used to analysis the P2Y6 receptor expression of immunohistochemical staining.