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. 2017 May 26;7:2466. doi: 10.1038/s41598-017-02397-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of A-to-I editing in different healthy human tissues. (A) A-to-I editing in mature miRNAs is the highest in Prefrontal cortex (two-tailed t-test; p = 0.003 with respect to lung samples). Percentage A-to-I editing was calculated by dividing the number of edited miRNAs by the total number of miRNAs expressed with a read count greater than equal to 10. The numbers above the bars represent the number of different individuals analysed. (B) C14 miRNA cluster show enriched A-to-I editing. The fraction of edited miRNAs from C14 was significantly higher compared to the miRnome average in all tissues analyzed (p < 0.008), the tissues have been arranged according to descending order of miRnome-wide editing.