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. 2017 May 26;7:2466. doi: 10.1038/s41598-017-02397-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neuron rich frontal cortex (FC) showed higher A-to-I editing in mature miRNAs than the corresponding corpus callosum (CC) of the same individuals. (A) FC showed higher A-to-I editing than CC of the same individuals (two-tailed t-test; p = 0.015). (B) Real-time PCR was done and delta Ct was plotted, ADAR2 (and not ADAR1, two-tailed t-test; p = 0.63) showed significant upregulation in FC compared to CC samples (two-tailed t-test; p = 0.008). B2M was used to normalize expression in all samples.