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. 2017 May 26;7:2466. doi: 10.1038/s41598-017-02397-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A-to-I edited miRNAs show predicted increased stability than their unedited forms. (A) The minimum free energy (MFE) for edited (“G” containing) and unedited (“A” containing) pre-miRNA was obtained using RNA fold. ΔΔG was calculated by subtracting MFE of unedited miRNA from edited miRNA. Negative value of ΔΔG means more stable edited forms. 55% (33/60) sites showed an increase in stability (ΔΔG < zero), 24 out of the 33 sites showed a value less than −6 Kcal/mole. (B) The motif for sequence preference in the pre-miRNA fold-back structure is analysed. For all the miRNAs that gained stability upon editing (ΔΔG < −6.0 Kcal/mole) the edited adenosines were found to have mis-paired cytosines on the pre-miRNA hairpin structure.