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. 2017 May 1;7(5):1136–1150.

Figure 5.

Figure 5

MiR-146b-5p regulates the expression of PDHB through post-transcriptional mechanism. A. Schematic illustration of the putative binding sites between wild-type or mutant 3’-UTR of PDHB and miR-146b-5p. B. Luciferase activity is decreased by miR-146b-5p mimic. C. MiR-146b-5p does not change the mRNA level of PDHB in CRC cell lines. D. MiR-146b-5p significantly changes the protein level of PDHB in CRC cell lines. E. The expression of PDHB mRNA in tumor xenograft is not affected by miR-146b-5p overexpression. F. The expression of PDHB protein in tumor xenograft is significantly repressed by miR-146b-5p overexpression. G. The expression level of miR-146b-5p is not associated with mRNA expression of PDHB in CRC specimen. H. The expression level of miR-146b-5p is negatively associated with mRNA expression of PDHB in CRC specimen. **P<0.01.