Table 3.
Cox univariate analysis of survival in 127 patients with cervical cancer
| Overall survival | Disease-free survival | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR | 95% CI | P value | HR | 95% CI | P value | |
| CIP2A | ||||||
| (-) vs (+) | 5.75 | 2.22-14.91 | <0.001 | 4.24 | 1.85-9.68 | 0.001 |
| E2F1 | ||||||
| (-) vs (+) | 2.11 | 0.69-6.50 | 0.192 | 1.44 | 0.49-4.23 | 0.509 |
| Tumor size | ||||||
| <4 vs ≥4 cm | 6.94 | 2.26-21.31 | <0.001 | 4.94 | 2.03-12.02 | <0.001 |
| LN metastasis | ||||||
| No vs Yes | 5.09 | 1.93-13.38 | 0.001 | 4.06 | 1.79-9.21 | 0.001 |
| Differentiation grade | ||||||
| Well-moderate vs poor | 2.14 | 0.79-5.80 | 0.134 | 1.77 | 0.77-4.10 | 0.181 |
| Age, years | ||||||
| ≤ 40 vs >40 | 1.18 | 0.42-3.36 | 0.752 | 1.78 | 0.66-4.80 | 0.253 |
| FIGO stage | ||||||
| I vs (II to IV) | 1.45 | 0.41-5.10 | 0.560 | 1.70 | 0.63-4.61 | 0.294 |
| Distant metastasis | ||||||
| No vs Yes | 2.24 | 0.64-7.84 | 0.208 | 2.08 | 0.70-6.13 | 0.185 |
| Depth of invasion | ||||||
| <1/2 vs ≥1/2 | 2.55 | 0.58-11.16 | 0.214 | 1.62 | 0.55-4.77 | 0.380 |
| Histotype | ||||||
| SCC vs AC | 0.80 | 0.11-6.07 | 0.831 | 1.23 | 0.29-5.27 | 0.778 |
| CIP2A and E2F1 | ||||||
| Co-expression(+) vs others | 7.76 | 2.52-23.87 | 0.003 | 5.24 | 1.77-15.48 | 0.003 |
| CIP2A and E2F1 | ||||||
| Co-expression(-) vs others | 0.30 | 0.12-0.78 | 0.013 | 0.42 | 0.18-0.95 | 0.038 |
HR, hazard ratio; 95% CI, 95% confidence interval.