The genes expression of ovarian tissues analyzed by real-time PCR. The effects of CRY on inhibin B, activin A and follistatin mRNA expression in rats with DHEA-induced PCOS in the following groups: control, DHEA and DHEA + CRY group. The expression of inhibin B mRNA (2.63 ± 0.23), and follistatin mRNA (3.77 ± 0.29) in DHEA group was increased significantly, while activin A mRNA (0.59 ± 0.17) was decreased significantly than in the control group (1.00 ± 0.00). After drug intervention, the expression of inhibin B mRNA (1.64 ± 0.31) and follistatin mRNA (1.35 ± 0.34) was statistically decreased, while activin A mRNA (1.17 ± 0.21) was increased significantly. The data are expressed as the mean ± SEM. *P < 0.05 versus control, #P < 0.05 versus DHEA.