Figure 6.

Schematic model showing the role of PGE1 in improving coronary microvascular dysfunction. Sodium laurate induces CME, causing decreased GSK-3β phosphorylation and mPTP opening, leading to damaged mitochondrial function and structure. The low anti-oxidative stress facilitates the expression of fgl2 and inflammatory infiltration. Finally, coronary microcirculation dysfunction induced early myocardial ischemia. However, PGE1 can prevent these molecular effects at the site of GSK-3β phosphorylation.