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. 2017 May 15;9(5):2608–2617.

Figure 2.

Figure 2

GC7 enhanced sensitivity to doxorubicin and regulated doxorubicin-induced EMT in epithelial phenotype HCC cells. A: GC7 reversed the expression of doxorubicin-induced EMT-markers in HCC cells. Western blotting was used to examine the expression of E-cadherin and Vimentin compared with control, treated with doxorubicin alone or with doxorubicin plus GC7 (*P < 0.05; **P < 0.01; ***P < 0.001). B: Immunofluorescence was performed to analysis the expression of E-cadherin and Vimentin in HCC cells. C-F: Cell viability was measured using a CCK-8 assay. GC7 (20 μM) significantly enhanced the cytotoxicity of doxorubicin in Huh7, Hep3B but had little synergistic effect in SNU387 and SNU449 cells.