Table 1.
A list of miRNAs demonstrated to target FOXO mRNAa
| miRNA | Target mRNA (FOXO isoform) | Target cell/tissue or biological process (organismb) | Reference |
|---|---|---|---|
| miR‐9 | FOXO1 | Breast cancer cells (Hs) | Yang et al. (2014a) |
| FOXO1 | Neural stem cell differentiation (Mm) | Kim et al. (2015) | |
| FOXO1 and FOXO3 | Haematopoietic cells (Hs and Mm) | Senyuk et al. (2013) | |
| miR‐10b | FOXO3 | Glioblastoma multiforme (Hs) | Lin et al. (2012) |
| miR‐21 | FOXO1 | Glioblastoma cells (Hs) | Lei et al. (2014a) |
| FOXO1 | Diffuse large B‐cell lymphoma (Hs) | Go et al. (2015) | |
| FOXO1 | Pancreatic ductal adenocarcinoma (Hs) | Song et al. (2015) | |
| miR‐23a | FOXO3 | Cardiac hypertrophy (Mm) | Wang et al. (2012b) |
| miR‐23b | FOXO4 | Vascular smooth muscle cells (Hs and Rn) | Iaconetti et al. (2015) |
| miR‐27a | FOXO1 | Renal cell carcinoma (Hs) | Zhou et al. (2012) |
| FOXO1 | Liver cancer (Hs and Mm) | Sun et al. (2015a) | |
| FOXO3 | Glioblastoma (Hs) | Ge et al. (2013) | |
| miR‐29a | FOXO3 | Chondrogenic differentiation of mesenchymal stem cells (Hs and Mm) | Guerit et al. (2014) |
| miR‐30d | FOXO3 | Cardiomyocyte pyroptosis in diabetic cardiomyopathy (Rn and Hs) | Li et al. (2014d) |
| miR‐96 | FOXO1 | Bladder cancer (Hs) | Guo et al. (2012) |
| FOXO1 | Prostate cancer (Hs) | Fendler et al. (2013) | |
| FOXO1 | Prostate cancer (Hs) | Haflidadottir et al. (2013) | |
| FOXO1 and FOXO3 | HepG2 hepatoma cells (Hs) | Xu et al. (2013a) | |
| FOXO3 | Breast cancer (Hs) | Lin et al. (2010) | |
| FOXO3 | Idiopathic pulmonary fibrosis fibroblasts (Hs) | Nho et al. (2014) | |
| FOXO3 | Non‐small cell lung cancer (Hs) | Li et al. (2015a) | |
| FOXO3 | Prostate cancer (Hs) | Wang et al. (2015a) | |
| miR‐107 | FOXO1 | Gastric cancer cells (Hs) | Li et al. (2014b) |
| miR‐126 | FOXO3 | Vascular smooth muscle cells (Hs and Mm) | Zhou et al. (2013) |
| miR‐132 | FOXO1 | Gastric cancer cells (Hs) | Li et al. (2015b) |
| FOXO3 | Acute inflammatory lung injury (Mm) | Rao et al. (2015) | |
| miR‐132‐3p | FOXO1 | Alzheimer's disease (Hs) | Lau et al. (2013) |
| miR‐135a | FOXO1 | Spermatogonial stem cells in cryptochorid testes (Rn) | Moritoki et al. (2014) |
| FOXO1 | Bladder cancer (Hs) | Mao et al. (2015) | |
| FOXO1 | Malignant melanoma cells (Hs) | Ren et al. (2015) | |
| miR‐135b | FOXO1 | Anaplastic large cell lymphoma (Hs) | Matsuyama et al. (2011) |
| FOXO1 | Hepatocellular carcinoma (Hs and Mm) | Jung et al. (2014) | |
| FOXO1 | Osteosarcoma cells (Hs) | Pei et al. (2015) | |
| miR‐137 | FOXO1 | Hepatocellular carcinoma (Hs) | Tan et al. (2015) |
| miR‐139 | FOXO1 | Mouse hepatocytes (Mm) | Hasseine et al. (2009) |
| miR‐145 | FOXO1 | White adipose tissue (Mm) | Lin et al. (2014) |
| miR‐155 | FOXO3 | Breast cancer (Hs) | Kong et al. (2010) |
| FOXO3 | Hypoxic lung cancer cells (Hs) | Babar et al. (2011) | |
| FOXO3 | Multifunctional Treg cell line (Hs) | Yamamoto et al. (2011) | |
| FOXO3 | Vascular stem cell niche in bone marrow (Hs) | Spinetti et al. (2013) | |
| FOXO3 | Glioma (Hs) | Ling et al. (2013) | |
| FOXO3 | Ulcerative colitis (Hs) | Min et al. (2014) | |
| FOXO3 | Lymphoproliferation in linker for activation of T‐cells (LAT) mutant mice (Mm) | Rouquette‐Jazdanian et al. (2015) | |
| FOXO3 | Pancreatic cancer (Hs) | Wang et al. (2015c) | |
| miR‐182 | FOXO1 | Activated helper T‐lymphocytes (Mm and Hs) | Stittrich et al. (2010) |
| FOXO1 | Osteoblasts and skeletogenesis (Mm and Dr) | Kim et al. (2012) | |
| FOXO1 | Rejecting cardiac allografts and mononuclear cell infiltrate (Mm) | Wei et al. (2012) | |
| FOXO1 | Hydrogen peroxide‐induced apoptosis in neuroblastoma cells (Hs) | Gheysarzadeh and Yazdanparast (2015) | |
| FOXO1 and FOXO3 | Colon cancer – African and Caucasian Americans (Hs) | Li et al. (2014a) | |
| FOXO3 | Melanoma metastasis (Hs and Mm) | Segura et al. (2009) | |
| FOXO3 | Advanced ovarian carcinoma (Hs) | McMillen et al. (2012) | |
| FOXO3 | Skeletal muscle (Mm and Rn) | Hudson et al. (2014) | |
| FOXO3 | High‐grade serous ovarian carcinoma (Hs) | Levanon et al. (2014) | |
| FOXO3 | Ovarian cancer cells – orthotopic xenografts (Hs) | Xu et al. (2014a) | |
| FOXO3 | Lung cancer (Hs) | Yang et al. (2014b) | |
| miR‐183 | FOXO1 | Human‐specific miR‐183 target site (Hs) | McLoughlin et al. (2014) |
| FOXO1 | Non‐small cell lung cancer cells (Hs) | Zhang et al. (2015a) | |
| miR‐196a | FOXO1 | Cervical cancer (Hs) | Hou et al. (2014) |
| miR‐205 | FOXO3 | Lung squamous cell carcinoma (Hs) | Huang et al. (2014) |
| miR‐217 | FOXO3 | Angiogenesis of cytomegalovirus‐infected endothelial cells (Hs) | Zhang et al. (2013) |
| miR‐223 | FOXO1 | Colorectal cancer, cervical cancer and hepatoma cells (Hs) | Wu et al. (2012a) |
| FOXO1 and FOXO3 | Analysis of decoy oligonucleotides as modulators of miRNA activity in various cell lines (Hs) | Wu et al. (2013) | |
| miR‐370 | FOXO1 | Prostate cancer cells (Hs) | Wu et al. (2012b) |
| FOXO1 | Gastric carcinoma (Hs) | Fan et al. (2013) | |
| miR‐374a | FOXO1 | Osteosarcoma (Hs) | He et al. (2015) |
| miR‐421 | FOXO4 | Nasopharyngeal carcinoma (Hs) | Chen et al. (2013) |
| miR‐486 | FOXO1 | Cardiac and skeletal muscle (Mm and Rn) | Small et al. (2010) |
| FOXO1 | Muscle wasting in chronic kidney disease (Mm) | Xu et al. (2012) | |
| FOXO1 | Cardiac/skeletal muscle cells in breast cancer and mouse models (Hs and Mm) | Chen et al. (2014) | |
| miR‐498 | FOXO3 | Ovarian cancer cells (Hs) | Liu et al. (2015) |
| miR‐499‐5p | FOXO4 | Colorectal cancer (Hs) | Liu et al. (2011) |
| miR‐582‐5p | FOXO1 | Monocytes (Hs) | Liu et al. (2013) |
| miR‐664 | FOXO4 | Osteosarcoma cells (Hs) | Chen et al. (2015) |
| miR‐708 | FOXO3 | Childhood acute lymphoblastic leukaemia (Hs) | Han et al. (2011) |
| miR‐1269 | FOXO1 | Hepatocellular carcinoma (Hs) | Yang et al. (2014c) |
| miR‐1274a | FOXO4 | Gastric cancer (Hs) | Wang et al. (2015b) |
a
Only reports on FOXO regulation by a single miRNA are listed here. For reports on FOXO regulation by several miRNAs simultaneously, see Table 2.
b
Hs, human; Mm, mouse; Rn, rat; Dr, zebrafish.