TABLE 1.
Description of adenoviral vectorsa
| Adenoviral vector | Receptor recognition characteristic | Protein targeted for mutation: region and domain mutated | Genetic mutation(s) |
|---|---|---|---|
| HAdV-5 | Native tropism | None | None |
| HAdV-5-EGFP | Native tropism | None | None |
| HAdV-5Luc | Native tropism | None | None |
| AdT* (HAdV-5HVR5*HVR7*E451Q) | FX-binding deficiency | Hexon: HVR 5 and 7 | T270P and E271G on HVR 5 and I421G, T423N, E424S, L426Y, and E451Q on HVR 7 |
| HAdV-5 KO1 | Greatly reduced CAR binding | Fiber: AB loop region of the fiber knob domain | S408E and P409A |
| HAdV-5/F35Luc | CAR-binding deficiency | Fiber | Serotyping of HAdV-5 with HAdV-35 fiber |
a
HAdV-5, human adenoviral vector serotype 5; HVR, hypervariable region; FX, coagulation factor X; CAR, coxsackievirus and adenovirus receptor.