Viral particles in rOka- and 7D-infected ARPE-19 cells. (A) rOka-infected ARPE-19 cells. Normal VZV particles were observed in the nucleus (a1 and a2, capsids with genome, green arrow; capsids without genome, blue arrow) and in the cytoplasm and on the cell surface (a3 and a4, intact virion, green arrow; hollow particle, blue arrow), respectively. (B) 7D-infected ARPE-19 cells. 7D nucleocapsids were observed in the nucleus (b1 and b2, capsids with genome, green arrow; capsids without genome, blue arrow). Envelope-defective particles (red arrows) were captured in the cytoplasm and on the cell surface (b3 and b4). “Nu” and “Cy” indicate the nucleus and the cytoplasm, respectively.