Table 1.

Exclusion criteria

Related to the OA pathology
○ Radiographical Kellgren and Lawrence grade I or IV  ○ Osteoarthritis secondary to a microcrystalline arthropathy: chondrocalcinosis previously known or defined by a calcium border on at least one tibiofemoral spacing, gout ……  ○ Isolated femoropatellar OA  ○ Presence of another joint (other than the evaluated knee) affected by OA (confirmed in radiographs and symptomatic)  ○ Chondromatosis or villonodular synovitis of the knee  ○ Paget disease  ○ Recent trauma (<1 month) of the evaluated knee  ○ Pathologies interfering with the evaluation of OA (radiculalgia in the lower limbs, arteritis…..)  ○ Acute inflammatory osteoarthritis (Kofus ≥ 7)
Related to previous and concomitant treatments
○ Corticosteroids injection in the evaluated knee in the last month before injection  ○ Hyaluronan injection in the evaluated knee in the last 6 months before injection  ○ Acetaminophen and NSAIDs 48 h before inclusion visit  ○ Change in the dosage of symptomatic slow-acting drugs i.e. chondroitin, glucosamine, diacerein or avocado-soybean unsaponifiables in the last 3 months before first injection  ○ Arthroscopy and surgery in the target knee in the last 3 months before first injection  ○ Oral corticotherapy
Related to associated pathologies
○ Severe diseases (liver or renal failure, uncontrolled cardiovascular diseases….)  ○ Other inflammatory rheumatic diseases (e.g. rheumatoid arthritis)  ○ Dermatological infection at the site of injection  ○ Anticoagulant treatment  ○ High risk of hemorrhage
Related to the patients
○ Allergy to hyaluronan and constituents (i.e. mannitol)  ○ Allergy to acetaminophen  ○ Pregnant or breastfeeding women  ○ Premenopausal women without contraception  ○ Unable to write  ○ Participation to a therapeutic clinical trial in the last 3 months  ○ Under guardianship or judicial protection