Table 2.

Secondary outcomes

Parameter	Method of analysis
Coll2-1	Decrease between inclusion (D-10) and D30 or D180
Lequesne index (LI)	Decrease between inclusion visit (D-10) and further visits
Global assessment of pain	Visual analog scale (VAS, 0–100 mm) between inclusion visit (D-10) and further visits
OMERACT/OARSI set of criteria	Percentage of responders at D90 and D180
Acetaminophen and NSAID consumption	Number of patients that required at least once rescue medication during the study
Patient’s global assessment of the disease activity	11 points Likert scale ranging of 0 (low active disease) to 10 (maximum activity)

Abbreviations: OMERACT Outcome Measures in Rheumatology, OARSI Osteoarthritis Research Society International, D-10 10 days before injection, D30, D90, D180 respectively 30, 90, and 180 days following injection