Table 2.
Comparison of Lauren subtypes, tumor location, average size and tumor tissue proportion of tumor fragments based on biopsy number and tumor fragment number
| Lauren subtypes, n (%) | P value | Tumor location, n (%) | P value | Average size (mean ± SD, cm) | P value | Tumor tissue proportion (%) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intestinal | Diffuse | Mixed | Indeterminate | Upper third | Middle third | Lower third | Others | |||||||
| Number of biopsy specimens | 0.112 | 0.445 | 0.977 | 0.204 | ||||||||||
| 1 | 6 (85.7) | 1 (14.3) | 0 (0.0) | 0 (0.0) | 2 (28.6) | 1 (14.3) | 4 (57.1) | 0 (0.0) | 0.194 ± 0.012 | 54.4 ± 10.9 | ||||
| 2 | 11 (55.0) | 6 (30.0) | 1 (5.0) | 2 (10.0) | 5 (25.0) | 6 (30.0) | 9 (45.0) | 0 (0.0) | 0.201 ± 0.056 | 56.7 ± 16.1 | ||||
| 3 | 12 (44.4) | 8 (29.6) | 7 (25.9) | 0 (0.0) | 10 (37.0) | 5 (18.5) | 11 (40.7) | 1 (3.7) | 0.192 ± 0.046 | 52.4 ± 15.6 | ||||
| 4 | 107 (51.2) | 56 (26.8) | 43 (20.6) | 3 (1.4) | 58 (27.8) | 53 (25.4) | 97 (46.4) | 1 (0.5) | 0.199 ± 0.038 | 51.0 ± 17.1 | ||||
| 5 | 68 (53.5) | 33 (26.0) | 26 (20.5) | 0 (0.0) | 39 (30.7) | 37 (29.1) | 51 (40.2) | 0 (0.0) | 0.195 ± 0.035 | 51.8 ± 17.9 | ||||
| 6 | 215 (49.7) | 131 (30.3) | 84 (19.4) | 3 (0.7) | 87 (20.1) | 137 (31.6) | 205 (47.3) | 4 (0.9) | 0.196 ± 0.041 | 53.4 ± 18,1 | ||||
| 7 | 12 (41.4) | 9 (31.0) | 7 (24.1) | 1 (3.4) | 6 (20.7) | 7 (24.1) | 16 (55.2) | 0 (0.0) | 0.193 ± 0.043 | 52.6 ± 18.9 | ||||
| 8 | 15 (45.5) | 10 (30.3) | 8 (24.2) | 0 (0.0) | 6 (18.2) | 14 (42.4) | 13 (39.4) | 0 (0.0) | 0.200 ± 0.039 | 48.5 ± 19.3 | ||||
| 10 | 2 (40.0) | 3 (60.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (40.4) | 3 (60.0) | 0 (0.0) | 0.202 ± 0.040 | 43.0 ± 15.7 | ||||
| Number of tumor fragments | 0.126 | 0.745 | 0.189 | 0.530 | ||||||||||
| 1 | 31 (60.8) | 14 (27.5) | 5 (9.8) | 1 (2.0) | 10 (19.6) | 11 (21.6) | 30 (58.8) | 0 (0.0) | 0.209 ± 0.042 | 48.8 ± 20.4 | ||||
| 2 | 46 (54.1) | 25 (29.4) | 11 (12.9) | 3 (3.5) | 15 (17.6) | 29 (34.1) | 41 (48.2) | 0 (0.0) | 0.190 ± 0.032 | 50.5 ± 18.9 | ||||
| 3 | 91 (53.2) | 50 (29.2) | 29 (17.0) | 1 (0.6) | 42 (24.6) | 49 (28.7) | 79 (46.2) | 1 (0.6) | 0.195 ± 0.039 | 50.2 ± 17.3 | ||||
| 4 | 184 (52.9) | 89 (25.6) | 73 (21.0) | 2 (0.6) | 92 (26.4) | 105 (30.2) | 148 (42.5) | 3 (0.9) | 0.197 ± 0.037 | 53.8 ± 17.0 | ||||
| 5 | 48 (41.0) | 39 (33.6) | 29 (23.9) | 1 (0.9) | 26 (22.2) | 37 (31.6) | 54 (46.2) | 0 (0.0) | 0.193 ± 0.040 | 52.2 ± 18.0 | ||||
| 6 | 47 (41.6) | 38 (33.6) | 27 (23.9) | 1 (0.9) | 28 (24.8) | 29 (25.7) | 54 (47.8) | 2 (1.8) | 0.199 ± 0.041 | 54.7 ± 17.7 | ||||
| 8 | 1 (25.0) | 1 (25.0) | 2 (50.0) | 0 (0.0) | 0 (0.0) | 1 (25.0) | 3 (75.0) | 0 (0.0) | 0.214 ± 0.026 | 52.5 ± 19.3 | ||||
| 10 | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 0.204 | 51.3 | ||||
“n” refers to the number of cases. “Average size” refers to average size of tumor-containing fragments. “Tumor tissue proportion” refers to tumor tissue proportion of tumor-containing fragments