Table 4.
Comparison of HER2 IHC positivity based on tumor-containing fragment number, biopsy specimen number, average size and tumor tissue proportion of tumor-containing fragments
| Total | HER2 | P value | ||
|---|---|---|---|---|
| 3+, n (%) | Non-3+, n (%) | |||
| Total | 890 | 100 (11.2) | 790 (88.8) | |
| Number of tumor-containing fragments | 0.004* | |||
| 1 | 51 | 1 (2.0) | 50 (98.0) | |
| 2 | 85 | 3 (3.5) | 82 (96.5) | |
| 3 | 171 | 12 (7.0) | 159 (93.0) | |
| 4 | 348 | 46 (13.2) | 302 (86.8) | |
| 5 | 117 | 20 (17.1) | 97 (82.9) | |
| 6 | 113 | 18 (15.9) | 95 (84.1) | |
| 8 | 4 | 0 (0) | 4 (100) | |
| 10 | 1 | 0 (0) | 1 (100) | |
| Number of biopsy specimens | 0.127 | |||
| 1 | 51 | 0 (0) | 7 (100) | |
| 2 | 85 | 0 (0) | 20 (100) | |
| 3 | 171 | 2 (7.4) | 25 (92.6) | |
| 4 | 348 | 14 (6.7) | 195 (93.3) | |
| 5 | 117 | 16 (12.6) | 111 (87.4) | |
| 6 | 113 | 61 (14.1) | 372 (85.9) | |
| 7 | 0 | 3 (10.3) | 26 (89.7) | |
| 8 | 4 | 4 (12.1) | 29 (87.9) | |
| 10 | 1 | 0 (0) | 5 (100) | |
| Average size of tumor fragements (cm) | 0.397 | |||
| ≤0.15 | 110 | 9 (8.2) | 101 (91.8) | |
| >0.15 ≤ 0.20 | 417 | 54 (12.9) | 363 (87.1) | |
| >0.20 ≤ 0.25 | 291 | 31 (10.7) | 260 (89.3) | |
| >0.25 | 72 | 6 (8.3) | 66 (91.7) | |
| Tumor tissue proportion of tumor fragments (%) | 0.825 | |||
| ≤30 | 132 | 13 (9.8) | 119 (90.2) | |
| >30 ≤ 50 | 324 | 40 (12.3) | 284 (87.7) | |
| >50 ≤ 70 | 289 | 30 (10.4) | 259 (89.6) | |
| >70 | 145 | 17 (11.7) | 128 (88.3) | |
“n” refers to the number of cases
*P <0.05