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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Genet Dev. 2017 Jan 6;42:8–13. doi: 10.1016/j.gde.2016.12.002

Figure 2.

Figure 2

Exploring two biologically plausible models for the acquisition of mosaicism. In the first model (a), a somatic event is acquired early in development during periods of rapid cellular growth and division, but the aberrant cells remain at low cellular proportions until later in life when changes in the cellular environment confer a selective advantage of aberrant clones over normal cells allowing them to expand to a detectable proportion of the cellular population. In the second model (b), somatic events are acquired later in life and soon after clonally expand to become a detectable proportion of the cellular population.