Table 4.
Mean levels of laboratory parameters at baseline and during exposure period
| Laboratory parameters | Imidapril | Amlodipine | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Mean | 95% CI | p value | N | Mean | 95% CI | p value | |
| Creatinine (mg/dL) | ||||||||
| Baseline | 57 | 0.62 | (0.59, 0.65) | Reference | 57 | 0.64 | (0.62, 0.67) | Reference |
| Exposure | 0.67 | (0.64, 0.7) | <0.0001* | 0.65 | (0.62, 0.69) | 0.4246 | ||
| eGFR (mL/min/1.73 m2) | ||||||||
| Baseline | 57 | 77.1 | (73.5, 80.7) | Reference | 57 | 73.1 | (69.7, 76.5) | Reference |
| Exposure | 71.2 | (67.6, 74.8) | 0.0002* | 73.9 | (68.8, 78.9) | 0.7031 | ||
| BUN (mg/dL) | ||||||||
| Baseline | 56 | 13.3 | (12.3, 14.3) | Reference | 55 | 12.6 | (11.7, 13.9) | Reference |
| Exposure | 13.9 | (12.9, 14.9) | 0.3292 | 13.6 | (12.6, 14.6) | 0.0544 | ||
| Sodium (mEq/L) | ||||||||
| Baseline | 54 | 140 | (140, 141) | Reference | 52 | 141 | (140, 142) | Reference |
| Exposure | 141 | (140, 142) | 0.2776 | 141 | (140, 142) | 0.318 | ||
| Potassium (mEq/L) | ||||||||
| Baseline | 54 | 4.1 | (4.0, 4.3) | Reference | 52 | 4.1 | (4.0, 4.2) | Reference |
| Exposure | 4.3 | (4.3, 4.4) | 0.0072* | 4.1 | (4.0, 4.2) | 0.3704 | ||
eGFR estimated glomerular filtration rate, BUN blood urea nitrogen, CI confidence interval
* p < 0.05 (exposure period vs baseline, paired t test)