Table 2.
Change in office supine blood pressure from baseline to week 12
| Per/Ind/Aml (n = 74) | Per/Ind + Aml (n = 70) | |
|---|---|---|
| SBP (mm Hg) | ||
| Baseline (mean ± SD) | 149.1 ± 4.9 (95% CI [147.9; 150.1]) | 149.0 ± 4.7 (95% CI [147.9; 150.1]) |
| Week 12 | 127.6 ± 11.1 (95% CI [125.0; 130.1]) | 129.0 ± 11.7 (95% CI [126.2; 131.8]) |
| Week 12−baseline | −21.5 ± 11.7 (95% CI [−24.3; −18.8]) | −20.0 ± 12.9 (95% CI [−23.1; −17.0]) |
| Estimatea ± SD | −1.4 ± 1.8 (95% CI [−5.1; 2.2]) | |
| DBP (mm Hg) | ||
| Baseline (mean ± SD) | 94.1 ± 3.0 (95% CI [93.4; 94.8]) | 94.1 ± 3.1 (95% CI [93.4; 94.9]) |
| Week 12 | 78.8 ± 8.0 (95% CI [76.9; 80.6]) | 79.3 ± 8.4 (95% CI [77.3; 81.3]) |
| Week 12−baseline | −15.3 ± 7.8 (95% CI [−17.1; −13.5]) | −14.8 ± 9.0 (95% CI [−17.0; −12.7]) |
| Estimatea ± SD | −0.5 ± 1.3 (95% CI [−3.1; 2.0]) | |
Comparison between groups during the study period (week 12−baseline) for the full analysis set (n = 144)
Aml amlodipine, CI confidence interval, Per perindopril, Ind indapamide, SD standard deviation
aEstimate (±standard deviation) of the difference in adjusted mean changes from baseline to last post-baseline value until week 12 [Per/Ind/Aml]−[Per/Ind + Aml] using a general linear model with treatment, baseline, and center as covariates