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. 2017 Mar 6;124(6):671–683. doi: 10.1007/s00702-017-1702-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Entorhinal cortex, frontal cortex and cingulate cortex were selected as regions affected early in disease progression to investigate the accumulation of pathology during increasing stages of disease progression and the impact on cognitive decline. Hyperphosphorylated tau (HP-_T) load in the entorhinal cortex positively correlated with neurofibrillary tangle (NFT) Braak stage (a) and negatively correlated with MMSE score (b) in AD and control cases. β amyloid load in the frontal cortex positively correlated with Thal phase (c) and negatively correlated with MMSE score (d) in AD and control cases. α-Synuclein (α-syn) load in the cingulate cortex positively correlated with McKeith criteria in dementia with Lewy body (DLB), Parkinson’s disease dementia (PDD) Parkinson’s disease (PD) and control cases (e) and negatively correlated with with MMSE scores in DLB, PDD and controls (f) (PD cases were not included as no MMSE scores were available for these cases)