Table 2.
Neocortical pathology burden of hyperphosphorylated tau, β amyloid, and α-synuclein and neuropathological criteria
| Braak NFT stage | ||||
|---|---|---|---|---|
| I/II (n = 47) | III/IV (n = 42) | V/VI (n = 57) | Statistic* | |
| HP-T load | ||||
| Frontal % (± SE) | 0.07 (0.01) | 0.10 (0.02) | 12.29 (2.48) | p < 0.001a |
| Temporal % (± SE) | 0.26 (0.14) | 0.60 (0.33) | 20.58 (2.85) | p < 0.001b |
| Parietal % (± SE) | 0.06 (0.02) | 0.70 (0.52) | 18.07 (2.90) | p < 0.001c |
| Occipital % (± SE) | 0.04 (0.01) | 0.37 (0.17) | 15.04 (2.56) | p < 0.001d |
| Thal Aβ phase | ||||||
|---|---|---|---|---|---|---|
| 1 (n = 13) | 2 (n = 7) | 3 (n = 11) | 4 (n = 5) | 5 (n = 45) | Statistic* | |
| Aβ load | ||||||
| Frontal % (± SE) | 0.13 (0.07) | 3.80 (1.80) | 2.91 (0.69) | 8.29 (1.20) | 12.80 (1.44) | p < 0.001e |
| Temporal % (± SE) | 0.26 (0.20) | 1.94 (1.07) | 3.00 (0.82) | 5.97 (1.42) | 10.76 (1.04) | p < 0.001f |
| Parietal % (± SE) | 0.09 (0.44) | 2.82 (1.73) | 2.82 (0.91) | 7.37 (1.87) | 10.63 (1.08) | p < 0.001g |
| Occipital % (± SE) | 0.17 (0.09) | 1.55 (0.79) | 2.27 (0.73) | 4.86 (1.07) | 7.02 (5.99) | p < 0.001h |
| McKeith criteria | |||
|---|---|---|---|
| Limbic (n = 7) | Neocortical (n = 36) | Statistic** | |
| α-Syn load | |||
| Frontal % (± SE) | 0.06 (0.04) | 0.20 (0.07) | ns |
| Temporal % (± SE) | 0.04 (0.02) | 0.17 (0.04) | p < 0.05 |
| Parietal % (± SE) | 0.05 (0.04) | 0.16 (0.06) | ns |
| Occipital % (± SE) | 0.02 (0.01) | 0.09 (0.03) | ns |
NFT neurofibrillary tangle, n number, HP-T hyperphosphorylated tau, SE standard error, Aβ amyloid beta, α-syn alpha-synuclein, ns not significant
* Kruskal–Wallis test, Pairwise post hoc Mann–Whitney U tests
** Mann Whitney U test
aI/II < III/IV (p < 0.01), I/II < V/VI and III/IV < V/VI (both p < 0.001)
bI/II < III/IV (p < 0.01), I/II < V/VI and III/IV < V/VI (both p < 0.001)
cI/II < III/IV (p < 0.01), I/II < V/VI and III/IV < V/VI (both p < 0.001)
dI/II < III/IV (p < 0.01), I/II < V/VI and III/IV < V/VI (both p < 0.001)
e1 < 3, 1 < 4, 1 < 5, 3 < 5 (all p < 0.001) and 2 < 5, 3 < 4 (p < 0.01)
f1 < 3, 1 < 4, 1 < 5, 2 < 5 3 < 5 (all p < 0.001) and 4 < 5 (p < 0.05)
g1 < 3, 1 < 4, 1 < 5, 3 < 5 (all p < 0.001) and 2 < 3 (p < 0.01)
h1 < 3, 1 < 4, 1 < 5 (all p < 0.001), 3 < 5 (p < 0.01) and 2 < 4 (p < 0.05)