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. 2017 May 14;2017:9584819. doi: 10.1155/2017/9584819

Figure 8.

Figure 8

Tempol inhibits carrageenan and complete Freund's adjuvant- (CFA-) induced hyperalgesia. Mice were treated with tempol (100 mg/kg) or vehicle 40 min before carrageenan or CFA intraplantar injection. Nociceptive thresholds to mechanical and thermal stimuli were measured 1–5 h after carrageenan injection (panels (a) and (b), resp.) and 1–7 days after CFA injection (panels (c) and (d), resp.). Results are expressed as means ± SEM (n = 6 per group per experiment, representative of two separate experiments) [∗p < 0.05 versus saline; #p < 0.05 versus carrageenan + vehicle for panels (a)-(b) and versus CFA + vehicle for panels (c)-(d) (ANOVA followed by Tukey's t-test)].