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Variables and their levels in the Box–Behnken design
| Variables | Levels
|
||
|---|---|---|---|
| −1 | 0 | +1 | |
| Independent variables | |||
| X1 (solid lipid:amount of lipid [w/w]) | 0.1 | 0.5 | 0.9 |
| X2 (total amount of lipid [w/v]) | 0.8 | 0.9 | 1 |
| X3 (total amount of surfactant [w/v]) | 0.2 | 0.3 | 0.4 |
|
| |||
| Dependent variables | Constraints | ||
|
| |||
| Y1 (entrapment efficiency) | Maximize | ||
| Y2 (particle size) | Minimize | ||
