Figure 3.

PARD3 modulates ESCC cellular malignant phenotypes. Images of cell apoptosis, proliferation, migration, and invasion (A–D) in Eca109 cells (normal controls), PARD3 siRNA-transfected cells, and overexpression of PARD3, respectively. PARD3 siRNA-transfected cells showed significantly higher cell proliferation, invasion, and migration than controls, which significantly increased the malignant phenotype of Eca109 cells. Overexpression of PARD3 increased cell apoptosis and decreased cell proliferation, invasion, and migration in the Eca109 cell line.