Table 1.
Clinical characteristics of the Southern Finland cohort (N = 32, data missing for five individuals) and the Finnish Genetics of Preeclampsia (FINNPEC) cohort participants in C3 sequencing and genotyping.
| Controls (N = 702) | Severe preeclampsia (PE) (N = 991) | p-Value* (compared to controls) | Severe PE |
p-Value* (compared to controls) | |
|---|---|---|---|---|---|
| The Sanger sequencing stage (N = 27) median (25th, 75th percentile) | |||||
| Age, years | 29.5 (26, 33) | 31 (27, 35) N = 986 | <0.001 | 31 (25, 33) | 0.742 |
| Pre-pregnancy body mass index, kg/m2 | 23 (20.8, 25.9) | 24 (21.3, 28) N = 988 | <0.001 | 22.5 (20.7, 24) | 0.132 |
| Highest systolic blood pressure (BP), mmHg | 125 (118, 133) | 171 (161, 184) | <0.001 | 170 (160, 180) | <0.001 |
| Highest diastolic BP, mmHg | 82 (78, 87) | 112 (107, 118) | <0.001 | 105 (100, 110) | <0.001 |
| Proteinuria (DU-prot, diurnal collection sample), g/d | 4.2 (1.8, 7.1) N = 927 | NA | 5 (1.7, 15.2) | 0.002 | |
| Proteinuria (U-prot, single sample), g/l, median (max, min)a | 1.3 (0.7, 3.2), N = 13 | 0.189 | NA | NA | |
| Proteinuria measured by dipstix N (% positive: +, ++, +++)b | 23 (3) | 54 (5.4) | 0.03 | NA | NA |
| Primipara N (%) | 377 (54) | 733 (73) | <0.001 | 31 (100) | 0.017 |
| Birth weight SD score | 0 (−0.6, 0.7) N = 700 | −1.3 (−2.0, −0.5) N = 990 | <0.001 | −1.7 (−2.3, −0.7) | <0.001 |
| Gestational age at birth, weeks | 40 (39, 41) | 37 (34, 38) | <0.001 | 36 (31, 38) | <0.001 |
*Mann–Whitney U (continuous) or χ2 (categorical), Fisher’s exact for small groups N < 5.
aAmong those with no diurnal protein available.
bAmong those with no quantitative (diurnal or single sample) protein measurement.
Values for continuous variables are median (25, 75 percentiles) unless otherwise indicated, the number of subjects is indicated where data are not available for all participants.
Proteinuria was also observed in 11 controls, who did not meet the diagnostic criteria of PE.