Table 2.
Six non-coding single nucleotide polymorphism (SNP) have independent allelic association to severe preeclampsia.
| Genomic position (Build 38) | SNP | Minor allele frequency in cases/controls | N | χ2 | p-Value | Odds ratio (CI95) |
|---|---|---|---|---|---|---|
| 19:6686493 | rs2241391 | 0.023/0.014 | 1,694 | 4.071 | 0.044 | 1.73 (1.009, 2.966) |
| 19:6696331 | rs2287848 | 0.441/0.405 | 1,693 | 4.163 | 0.041 | 1.155 (1.006, 1.327) |
| 19:6696586 | rs2287845 | 0.441/0.405 | 1,693 | 4.328 | 0.038 | 1.158 (1.009, 1.331) |
| 19:6697818 | rs366510 | 0.441/0.405 | 1,693 | 4.283 | 0.039 | 1.158 (1.008, 1.330) |
| 19:6719442 | rs190390034 | 0.078/0.011 | 123 | 7.72 | 0.005 | 7.627 (1.442, 40.35) |
| 19:6720961 | rs183805948 | 0.031/0 | 123 | 5.734 | 0.017 | NA |
CI95, 95% confidence intervals; NA, not available (the variant was not observed in controls).