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. 2017 May 29;9:162. doi: 10.3389/fnagi.2017.00162

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Copyright © 2017 French, Ma, Oh, Tseng and Sibille.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distributions of BA11/47 age-related gene rankings in the genomic, somatostatin (Sst) cyclindependent kinase 6 (Cdk6) and synaptic transmission contexts. Each black line marks a gene, with blue lines for genes enriched in Sst Cdk6 transcriptomic types and annotated for synaptic transmission. The first row of lines shows the overrepresentation of age-associated down-regulation genes within synaptic transmission genes (area under the receiver operating curve), (area under the receiver operating curve, AUROC = 0.36, 660 genes). The second row of marks shows the Sst Cdk6 enriched genes that are evenly distributed across the age-associated gene ranking (AUROC = 0.5, 389 genes). The last row shows only the Sst Cdk6 enriched genes and marks the genes also annotated for synaptic transmission which are mostly age down-regulated (AUROC = 0.16, 25 genes).