Table 2.
Brain network-based analysis of the most common neurodegenerative diseases.
| Disease | Networks identified | Reference |
|---|---|---|
| AD | MAPK/ERK and clathrin-mediated receptor endocytosis | Hallock and Thomas (2012) |
| Immune system and microglia | Zhang et al. (2013) | |
| Astrocyte-specific and microglia-enriched modules | Miller et al. (2013) | |
| Myelination and innate immune response | Humphries et al. (2015) | |
| Network modules of AD progression | Kikuchi et al. (2013) | |
| Co-expression modules based on APOEɛ4 stratification | Jiang et al. (2016) | |
| Downregulated network of genes corresponding to metastable proteins prone to aggregation | Ciryam et al. (2016) | |
| Hypomethylation patterns in a myelination network | Humphries et al. (2015) | |
| PD | Stress response and neuron survival/degeneration mechanisms | Corradini et al. (2014) |
| Key protein targets including p62, GABARAP, GBRL1 and GBRL2 that modulated 1-methyl-4-phenylpyridinium (MPP+) toxicity | Keane et al. (2015) | |
| Alvespimycin neuroprotective agent for PD | Gao et al. (2014) | |
| RGS2 as a key regulator of LRRK2 function | Dusonchet et al. (2014) | |
| Downregulation of RNA and protein expression of a network of transcription factors FOXA1, NR3C1, HNF4A and FOSL2 | Fernández-Santiago et al. (2015) | |
| HD | Modules associated with Htt CAG length and toxicity | Langfelder et al. (2016) |
| Metalloprotein, stress response, angiogenesis, mitochondrion, glycolysis, intracellular protein transport, proteasome, synaptic vesicle | Neueder and Bates (2014) | |
| Protein modification, vesicles transport, cell signaling and synaptic transmission | Mina et al. (2016) | |
| Astrocyte module associated with TGFβ -FOXO3 signaling, stress and sleep phenotype | Scarpa et al. (2016) | |
| Aging, neurodegeneration | DNA repair, RNA metabolism, and glucose metabolism shared in AD and PD | Calderone et al. (2016) |
| 242 genes enriched in pathways related to neuron differentiation, apoptosis, gap junction trafficking, and cellular metabolic processes in AD and HD | Narayanan et al. (2014) | |
| Inflammation, mitochondrial dysfunction, and metal ion homeostasis in aging and PD | Glaab and Schneider (2015) | |
| Chaperome critical to maintain protein homeostasis in aging and neurodegeneration | Brehme et al. (2014) |