Table 2.

Cox regression.

	Multivariate HR for OS			Multivariate HR for RFS
Variable	HR	95% CI	P	HR	95% CI	P
Age at diagnosis
<50	Reference			Reference
≥50	1.03	0.54–1.96	0.93	0.79	0.38–1.62	0.51
ELN
Favorable	Reference			Reference
Intermediate	2.37	1.08–5.19	0.03	1.58	0.69–3.62	0.28
Leucocytosis at diagnosis
<50 G/L	Reference			Reference
≥50 G/L	1.01	0.49–2.06	0.99	0.93	0.41–2.11	0.86
Consolidation
No allo-SCT	Reference			Reference
Allo-SCT	0.32	0.13–0.79	0.01	0.50	0.19–1.33	0.17
Natural killer (NK) maturation profile
Hyper/intermediate	Reference			Reference
Hypomaturation	4.15	1.58–10.87	0.004	8.23	2.51–26.94	<0.001

Multivariate Cox regression models were used to assess the predictive value of NK maturation profile while adjusting for the prognostic factors in the population (age at diagnosis, ELN, leukocytosis, and allo-SCT as a time-dependent covariate).

Allo-SCT, allogeneic stem cell transplantation; CI, confidence interval; RFS, relapse-free survival; ELN, European Leukemia Net genetic classification; HR, hazard ratio; OS, overall survival.