Figure 3.

APE1 redox chaperone activity. Schematic representation of APE1 redox chaperone activity. Cysteine residues located within the DNA binding domain or regulatory domain of transcription factors are maintained in a reduced state by APE1, involved in a redox cycle with reducing molecules as TRX. The detailed redox mechanism by which APE1 controls the activity of transcription factors needs further investigation. [Image modified, with permission from the copyright holder, from Tell et al. (114) Cell Mol Life Sci].