Table 1.
NADPH oxidase family members.
| Family member | Regulator | Biological function | Reference |
|---|---|---|---|
| NOX1 | NOXO1; NOXA1; RAC1; p22phox | Host defense; growth factor and hormone (e.g., AngII) signaling. | (54–56) |
| NOX2 | P47phox; p67phox; p40phox; Rac1; p22phox | Oxidative burst; ER-stress-induced apoptosis; AngII signaling. | (50, 57, 58) |
| NOX3 | NOXO1; p22phox | Development of otoconia crystals. | (59) |
| NOX4 | p22phox | ER-stress-induced apoptosis. | (49) |
| NOX5 | Ca2+; phosphorylation | Spermatozoa motility; endothelial cell proliferation and capillary formation; smooth muscle cell proliferation and migration. | (60–62) |
| DUOX1 | Ca2+ | Thyroid hormonogenesis. | (63) |
| DUOX2 | Ca2+ | Host defense; iodination of thyroid hormone. | (56, 64) |