Figure 1.

Effect of saeS or saeRS null mutation and complementation on survival of S. aureus in human blood. Percent survival of wild-type S. aureus HA-MRSA WCUH29 (A), USA300 CA-MRSA 923 (B), USA400 CA-MRSA MW2 (C), and saeRS null mutants in freshly collected heparinized human blood with appropriate antibiotics. Bacteria were cultured overnight, diluted, inoculated into blood, and incubated at 37°C in a rotisserie incubator. Percent survival = (#CFU_final/#CFU_input)^*100. The data represents the mean ± SEM of at least six independent experiments.