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. 2017 May 29;8:307. doi: 10.3389/fphar.2017.00307

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Copyright © 2017 Hewitson, Holt, Tan, Wigg, Samuel and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OMX super-resolution microscopy demonstrating the effect of TGF-β1 on the nuclear distribution of H3K9Me3 marks. Volume rendered images showing effect of TGF-β1 on distribution of H3K9Me3, and its relationship with the nuclear envelope. H3K9Me3 marks are shown in green with individual nuclear pores seen with red NUP62 staining. Refer to Supplementary Figure S3 for representative optical cross sections of immunofluorescent staining before image stacking and volume rendering. Figure shows the top 2 μm of nuclei from cells grown in (A) control media and (D) media supplemented with 1 ng/ml TGF-β1. A transverse cross section of each is indicated by the green box, and illustrated in (B,E). A higher magnification of the areas marked in yellow (C,F) clearly shows the relative position of NUP62 and H3K9Me3 with and without TGF-β1 stimulation.