Table 2. Univariate and Multivariate Cox Proportional Hazards Regression Analysis of Risk Factors for Overall Survival in TNBC Patients.
| Parameters | Univariate Cox analysis | Multivariate Cox analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | p value | HR | 95%CI | p value | |||
| Lower | Higher | Lower | Higher | |||||
| miR-34a (low) | 2.062 | 1.164 | 3.654 | 0.013 | 0.875 | 0.371 | 2.061 | 0.759 |
| miR-34b (low) | 1.515 | 0.871 | 2.638 | 0.142 | - | - | - | - |
| miR-34c (low) | 2.474 | 1.373 | 4.460 | 0.003 | 3.075 | 1.293 | 7.311 | 0.011 |
| Age (>50) | 1.153 | 0.883 | 2.659 | 0.129 | - | - | - | - |
| Menstrual status (postmenopause) | 1.194 | 0.690 | 2.064 | 0.527 | - | - | - | - |
| Tumor grade (III) | 1.790 | 1.031 | 3.108 | 0.039 | 2.071 | 1.168 | 3.671 | 0.013 |
| Tumor size (>2 cm) | 1.450 | 0.827 | 2.542 | 0.195 | - | - | - | - |
| Lymph node status (positive) | 2.107 | 1.188 | 3.734 | 0.011 | 1.881 | 0.979 | 3.612 | 0.050 |
| Metastasis (positive) | 2.871 | 1.624 | 5.078 | <0.001 | 2.249 | 1.129 | 4.480 | 0.021 |
| Surgery | 0.317 | 0.181 | 0.554 | <0.001 | 0.684 | 0.319 | 1.468 | 0.330 |
| Chemotherapy | 0.653 | 0.090 | 4.740 | 0.674 | - | - | - | - |
| Radiotherapy | 2.514 | 1.248 | 5.064 | 0.010 | 1.403 | 0.605 | 3.256 | 0.431 |
TNBC, triple-negative breast cancer; HR, hazard ratio; CI, confidence interval; miR-34, microRNA-34.
Data are presented as HR, 95% CI and p value. A p value <0.05 was considered statistically significant. Significance was determined by univariate Cox proportional hazards regression analysis, and all factors with a p value <0.1 were further analyzed by multivariate Cox proportional hazards regression.