Table 3. Risk Factors Analysis for Overall Survival in TNM Stage I–III Patients.
| Parameters | Univariate Cox analysis | Multivariate Cox analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| Lower | Higher | Lower | Higher | |||||
| miR-34a (low) | 1.512 | 0.751 | 3.044 | 0.246 | - | - | - | - |
| miR-34b (low) | 1.012 | 0.506 | 2.025 | 0.973 | - | - | - | - |
| miR-34c (low) | 1.877 | 0.917 | 3.840 | 0.085 | 2.206 | 1.059 | 4.599 | 0.035 |
| Age (>50) | 1.931 | 0.943 | 3.955 | 0.072 | 1.571 | 0.727 | 3.396 | 0.251 |
| Menstrual status (postmenopause) | 1.454 | 0.700 | 3.018 | 0.315 | - | - | - | - |
| Tumor grade (III) | 2.353 | 1.175 | 4.712 | 0.016 | 2.270 | 1.098 | 4.692 | 0.027 |
| Tumor size (>2 cm) | 1.170 | 0.581 | 2.358 | 0.661 | - | - | - | - |
| Lymph node status (positive) | 2.457 | 1.186 | 5.088 | 0.016 | 1.463 | 0.578 | 3.706 | 0.422 |
| Surgery | 0.272 | 0.129 | 0.572 | 0.001 | 0.545 | 0.195 | 1.525 | 0.248 |
| Chemotherapy | 0.488 | 0.066 | 3.591 | 0.481 | - | - | - | - |
| Radiotherapy | 1.909 | 0.894 | 4.074 | 0.095 | 1.407 | 0.574 | 3.446 | 0.456 |
HR, hazard ratio; CI, confidence interval; miR-34, microRNA-34.
Data are presented as HR, 95% CI and p value. A p value <0.05 was considered statistically significant. Significance was determined by univariate Cox proportional hazards regression analysis, and all factors with a p value <0.1 were further analyzed by multivariate Cox proportional hazards regression.