Table 4. Risk factors Analysis for Overall Survival in TNM Stage IV Patients.
| Parameters | Univariate Cox analysis | Multivariate Cox analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| Lower | Higher | Lower | Higher | |||||
| miR-34a (low) | 3.414 | 1.133 | 10.283 | 0.029 | 0.919 | 0.151 | 5.591 | 0.927 |
| miR-34b (low) | 3.328 | 1.204 | 9.202 | 0.020 | 1.734 | 0.434 | 6.924 | 0.436 |
| miR-34c (low) | 4.264 | 1.416 | 12.838 | 0.010 | 3.175 | 0.588 | 17.133 | 0.179 |
| Age (>50) | 1.083 | 0.448 | 2.614 | 0.860 | - | - | - | - |
| Menstrual status (postmenopause) | 2.004 | 0.801 | 5.011 | 0.137 | - | - | - | - |
| Tumor grade (III) | 1.311 | 0.490 | 3.505 | 0.589 | - | - | - | - |
| Tumor size (>2 cm) | 2.067 | 0.728 | 5.868 | 0.172 | - | - | - | - |
| Lymph node status (positive) | 1.255 | 0.491 | 3.207 | 0.636 | - | - | - | - |
HR, hazard ratio; CI, confidence interval; miR-34, microRNA-34.
Data are presented as HR, 95% CI and p value. A p value <0.05 was considered statistically significant. Significance was determined by univariate Cox proportional hazards regression analysis, and all factors with a p value <0.1 were further analyzed by multivariate Cox proportional hazards regression.